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1. Chiarugi D, Degano P, Marangoni R A systems biology approach to the functional screening of genomes Meeting: BITS 2006 - Year: 2006 Full text in a new tab Topic: Computational systems biology Abstract: Missing |
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2. Corsi C, Ferragina P, Marangoni R The bioPrompt-box: an ontology-based clustering tool for searching in biological databases Meeting: BITS 2006 - Year: 2006 Full text in a new tab Topic: Miscellanea Abstract: Missing |
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3. Felicioli C, Cangelosi D, Cercignani G, Chiarugi D, Deiana N, Fabbiano S, Freschi L, Fulgentini L, Lucia S, Marangoni R Simulating signaling pathways: the motile photoresponse of H. salinarum as a case study Meeting: BITS 2009 - Year: 2009 Full text in a new tab Topic: Networks and Systems Biology Abstract: Missing |
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4. Galfrè S, Morandin F, Cozza A, Pellegrini S, Marangoni R A method to improve microarray-based identification of SNPs Meeting: BITS 2004 - Year: 2004 Full text in a new tab Topic: Unspecified Abstract: Single Nucleotide Polymorphism (SNP) represents a variation in sequence (polymorphism) between individuals caused by a change in a single nucleotide. This process is responsible for most of the genetic variation between individuals. Furthermore, the identification of distinct SNPs may play a crucial role in assessing a potential genetic influence for those disorders that do not appear to have a simple genetic transmission. In turn, the identification of genetic risk factors may contribute to determine biological markers of disease that can be used for the preclinical diagnosis of a pathological condition. Early diagnosis is important for enacting successful therapeutic strategies. In order to obtain more informative data, multiple SNPs should be tested simultaneously in the same individuals. A common protocol used in SNPs investigations is based on Single Base Extension (SBE) followed by microarrays hybridization, in which each DNA sample is hybridized on two arrays: one used to explore the existence of “A” and “T” in the SNP locus, the other array for “C” and “T”. To obtain a global evaluation of the frequency with which each SNP is represented in the population, it is necessary to make a quantitative comparison of the signals recorded from the two arrays. Because of many technical reasons, during this step a large quantity of noise is introduced, thus compromising the reliability of the final data. Here we present a simple approach, based on the usage of three arrays instead of only two, which can address this problem. We also give a statistics method for data processing to be used with the proposed experimental protocol. |
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5. Marangoni R Simulating genes families Meeting: BITS 2004 - Year: 2004 Full text in a new tab Topic: Unspecified Abstract: After their complete sequentiation, genomes are clusterized in genes families, the members of which share a significant similarity in their sequences (and often in the structures of their proteic products) but they are often playing different biological roles. When there is such a relationship between two genes, they are called paralogs. It is of general believe, that paralogs genesis is due to an iterate mechanism of gene duplication with subsequent modification of the copies. In a previous work describing a method to reconstruct the history of genes families, a simulator of genes families was introduced in order to bypass the lack of experimental data about genes families history. Working with these simulated data, some interesting features concerning real biological families has been found. Nevertheless, they have not been explored, since they were too far from the main subject of that paper. In the present work, a simulator similar to that used in the above cited paper has been developed, and many different synthetic data have been generated. The simulation strategy, the biological foundation of it and the comparison between simulated and real sequences are discussed in detail in the poster. |
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6. Marangoni R, Barison V, Cossi M, Gottardi R, Raiteri R Protein imaging via AFM: a feasibility study. Meeting: BITS 2007 - Year: 2007 Full text in a new tab Topic: Structural biology and drug design Abstract: Missing |
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7. Menconi G, Battaglia G, Pisanti N, Grossi R, Marangoni R Towards Mobilome Inference in Yeast Genomes Meeting: Proceedings of BITS 2010 Meeting - Year: 2010 Full text in a new tab Topic: Molecular Evolution and Comparative Genomics Abstract: Missing |
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8. Menconi G, Conti V, Puliti A, Sbrana I, Marangoni R A linguistic approach towards the functional characterization of intragenic non-exon sequences Meeting: BITS 2009 - Year: 2009 Full text in a new tab Topic: Novel methods and algorithms Abstract: Missing |
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9. Menconi G, Dionisi F, Marangoni R Extraction of recurrent motifs synthetic genomic sequences via dictionary-based compression Meeting: BITS 2006 - Year: 2006 Full text in a new tab Topic: Computational genetics Abstract: Missing |